Nick is bewitched by his cool new phone. A call from “Pharmacy Boy” turns Matthew into a nervous wreck. Jay finds a Netflix show made just for him.

Cellsea goads Nick into posting a risqué video, Maury urges Matthew to speed things up with Aiden, and Jay feeds Missy ideas for her erotic fiction.

While Nick tags along with the Gloubermans on a wild road trip to Florida, Jay discovers he’s been “Home Alone’d” — and moves in with a new family.

Connie gives Jessi a crash course in female pleasure, Maury tries to talk Andrew into sending a dick pic, and Nick lashes out at his new housemate.

The ghost of Duke Ellington takes Nick and friends on a journey back in time to 1913: the year he lost his virginity and found his true calling.

As the friends feverishly swap lists of the hottest kids at school, newcomer Ali stokes the flames by announcing she’s pansexual.

A big standardized test sends everyone into a panic — except for Jay, who just scored an Adderall prescription.

A provocative school musical unleashes Missy’s inner thespian — and her new Hormone Monstress. The “Queer Eye” Fab Five pay a visit to Coach Steve.

When a freak storm gives everyone new superpowers, tensions between Andrew, Nick and friends boil over into an epic showdown.

Sappy cards. Stupid clichés. And so much pressure. For Andrew, Nick, Jessi and friends, Valentine’s Day is a total freaking minefield.

Family blowups, secret liaisons and an unflattering dress make Jessi’s bat mitzvah a night to remember.

Andrew tries to drown his sorrows in a sea of porn, only to become hopelessly addicted. Coach Steve becomes a suspect in a murder spree.

Andrew struggles to blend in after a growth spurt, Nick worries his hormones are out of whack, and Jessi and Jay get a taste of the teen runaway life.

A classmate’s booming bosom sends the boys into a rapture — and leaves the girls with a raging case of insecurity. Coach Steve drops a bombshell.

As Nick tries to figure out whether he has a shot with Gina, a mortifying encounter with Leah sends Andrew into a spiral of shame.

Coach Steve finally gets his chance to do sex on a lady, Nick and Andrew go on a double date, and Jessi’s rebellious streak leads to big trouble.

An argument in sex ed class turns into a skit-tastic journey through the worlds of Planned Parenthood, contraceptives and STDs.

Jessi and Nick dip into her dad’s stash of edibles, with mind-bending results. Andrew searches for the right moment to break up with Lola.

While helping Greg move into a seedy bachelor complex, the boys and their dads debate what women want — and what it means to be a man.

A school sleepover turns messy as Nick dishes on a makeout session and the Shame Wizard works his miserable magic on the whole class.

Nick tries to lighten the mood at the sleepover with a new twist on Truth or Dare. The Shame Wizard meets his match. Jessi vows to change her ways.

After traveling through a magic portal to puberty headquarters, Nick seeks out a new Hormone Monster and Jessi bonds with the Depression Kitty.

As Andrew falls under the spell of the randy Hormone Monster, his buddy Nick becomes obsessed with the lack of changes in his own body.

A field trip goes from awkward to mortifying as Jessi navigates the demands of coupledom and gets her first period — inside the Statue of Liberty.

A trailer for a new movie starring The Rock leaves Andrew questioning his sexuality. Jessi and Nick’s budding romance turns ugly fast.

While the boys head to Jay’s for a testosterone-fueled sleepover, Jessi throws a party of her own and gets caught up in mean-girl drama.

A steamy novel making the rounds at school inspires Jessi to explore her own sexuality — and leaves the boys totally confused about what girls want.

Nick drags Andrew into the city to visit an old camp crush, but the day doesn’t go as planned. Jay embarks on an emotional journey with his pillow.

Andrew struggles to keep the Hormone Monster in check as he works with Missy on a science fair project. Jessi and Matthew have fun at Jay’s expense.

When Leah hosts a party for the high school drama crowd, Nick wrestles with a romantic dilemma, and Andrew and Missy witness a disturbing scene.

A sudden outbreak of body-swapping yields awkward situations and poignant revelations galore.

With two months left in eighth grade, the incoming freshmen tour their new high school with junior hosts while Jay evades his terrifying brothers.

A doctor puts Andrew on testicular rest, Nick asks Jay to help him get in shape for high school and Jessi becomes fascinated by Caitlin’s breastfeeding.

With no distractions, Andrew’s schoolwork improves — winning his father’s praise. Jessi goes a little too far when trying to emulate cool, mature Leah.

While Andrew and Nick follow Judd to Brooklyn to score drugs, Jay gets jealous of Kurt and Lola’s relationship, and Jessi oversteps at Matthew’s house.

As graduation day nears, Nick must decide if he will attend Cobblestones Academy while Andrew goes on an apology tour after being voted “Grossest Human.”

Big Mouth goes global for a very special episode as Maury and Connie take a closer look at how kids around the world experience puberty.

Andrew takes a liking to his new neighbor — and her mom. Nick wants to be more than Danni’s friend, but her entanglement with Travis gets in the way.

At their first high school party, Andrew discovers his talent for drinking games, Nick hopes for a shot with Danni, and Missy meets a potential rebound.

During a sleepover, Jay teaches Andrew how to defend himself against bullies. Then, Missy gets overwhelmed while back-to-school shopping with Jessi.